Stem cell research at Yale targeting cardiovascular disease

11-10-stem-cell


NEW HAVEN, Conn. (WTNH) – The fight against heart disease is the focus of Yale scientists working with stem cells.

Bio-engineered smooth tissue, made of stem cells, induced from blood cells directly taken from patients with cardiovascular disease.

It’s an example of the ongoing work at Yale Cardiovascular Research and Stem Cell Centers.

Yale scientist – Dr. Biraja Dash – led the team that created a vessel ring, which mimics a human blood vessel.

The goal — to test the effectiveness of approved FDA drugs for potential use among heart patients.

Dr. Dash says, “With the ring, we can literally see whether these movements are going on inside or not, so if we treat it with a drug and the smooth muscles doesn’t grow in, then that’s the drug for you to go to the next level for clinic.”

Still – it’s likely five years away from benefiting patients.

“Our scientists,” says Dr. Yibing Qyang at Yale School of Medicine, “are very excited to discover new medicines or new cardiovascular tissue to treat patients with cardiovascular disease.”

He adds, they are taking a more personalized stem cell approach, constructing tissue, to treat specific groups of patient.

“Then we can test multiple drugs on the target and find the most efficacious drug that can treat the patient.”

And there’s more.

There’s a beating vascular ring — a potential bypass.

It’s the concept of Dr. Jiesi Luo.

“For some patient,” says Dr. Luo, “with a problem in their septum in the heart, so it’s a by-pass and they need to feed the blood directly to the pulmonary artery.”

The advancements here, thanks to state and federal funding.

WTNH NEWS8 provides commenting to allow for constructive discussion on the stories we cover. In order to comment here, you acknowledge you have read and agreed to our Terms of Service. Commenters who violate these terms, including use of vulgar language or racial slurs, will be banned. Please be respectful of the opinions of others. If you see an inappropriate comment, please flag it for our moderators to review. Also, you can now block any inappropriate user by simple selecting the drop down menu on the right of any comment and selection "Block User" from there.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s