Officials say the 37-year-old woman was operating a motorcycle on Main Street at Caroline Street just before 7 p.m. when it collided with a car.
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The woman was transported to a local hospital where police say she is in critical but stable condition.
Derby Police believe the woman was at fault in the crash.
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The incident closed Route 34 for approximately two hours.
Anyone with information on the crash is asked to contact the Derby Police Department at (203) 735-7811.