According to officials, emergency crews were called to the area of 1169 Meriden-Waterbury Turnpike at Birch Drive just before 8 p.m.
Southington Police say a car smashed into a motorcyclist and then hit a nearby building.
The motorcyclist was taken to a local hospital with serious injuries to his leg. His identity has not been released.
It is not known if the driver of the car will face any charges.